Title : Secret sedative: How Missouri uses pentobarbital in executions
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Secret sedative: How Missouri uses pentobarbital in executions
Missouri will use 2 of its 34 vials of the sedative pentobarbital on Tuesday when it executes Marcellus Williams, who was convicted in the 1998 killing of Felicia Gayle, former St. Louis Post-Dispatch reporter.
The state has enough pentobarbital for 17 executions, Williams' included, according to a document obtained by St. Louis Public Radio. No one except the state of Missouri knows where the stockpile comes from, despite lawsuits from inmates and media outlets.
But there is 1 sure thing, according to 2 people who've witnessed executions in Missouri and Georgia: Pentobarbital is a potent means of death.
The FDA-approved manufacturer of the drug will not sell directly to any state for use in an execution and has made it clear it doesn't want 3rd-party distributors to do so. Any compounding pharmacy that makes small, quick-to-expire batches is shielded from public knowledge, too.
St. Louis Public Radio's Erica Hunzinger explains how pentobarbital works and why Missouri's source is still a secret 4 years after the state began using it in executions.
Experts argue that such secrecy makes it difficult to know whether Missouri's capital punishment process is constitutional.
"With a policy that is as important as the death penalty, and that has results that are so final and irreversible, it's important that the policy be carried out in the light of day," said Rob Dunham, the executive director of the nonprofit Death Penalty Information Center.
What is pentobarbital?
Simply, pentobarbital is "a drug that slows down the electrical activity of the brain and nerve cells," according to Dr. Aarti Sarwal, a neurologist and the medical director of the critical care unit at Wake Forest Baptist Medical Center in Winston-Salem, North Carolina.
Pentobarbital is used in humans and animals. In a veterinary setting, it's mostly for euthanasia, Dr. John Dodam, a professor at the University of Missouri-Columbia's veterinary school, said. He noted the pentobarbital used in that situation is for animals only and has species-specific versions of the drug.
For humans, it's mostly used in operating rooms and intensive care units to treat uncontrolled seizures and brain swelling. When injected, the drug goes to the heart and is pumped throughout the body.
Sarwal noted: "It's unique in a manner that it reaches the brain tissue very efficiently."
She described how pentobarbital affects a body when used in operating rooms and ICUs to treat uncontrolled seizures and brain swelling. What follows does not address executions.
"It slows down the activity in the brain - it essentially puts you to sleep - and, as the doses go higher, into almost a state of coma to the point of completely shutting down. (The) rest of the body is controlled by nerve cells, so similar effects happen there ... the nerves that affect your heart muscles ... get slowed down, so the heart muscles will start beating slower and slower, essentially to the point of lowering your blood pressure. ...
"Same happens for breathing: The brain centers that regulate your breathing, as well as the nerve cells that help the breathing muscles work, get slowed down. ... It also has several other effects, like slowing down your stomach activity and pretty much any other activity in the body that's controlled by nerve cells," she said.
And it isn't a drug that just any doctor can prescribe, Sarwal cautioned.
"Pentobarbital is a drug that has to be given by qualified providers who are specifically trained to monitor the dosing and side effects ... So, this is not part of typical medical school training. (Doctors) do get trained in understanding the side effects but it does require special training, and the use of pentobarbital is restricted to specific professions," she said.
Why executions?
Ohio was the 1st state to use a single-drug pentobarbital protocol in executions in 2011 (it changed to a two-drug protocol a couple of years later when pentobarbital became tougher to purchase). Texas followed in 2012, with Georgia and Missouri joining in 2013 and Tennessee in 2015.
Other drugs, mostly used in 2- or 3-drug protocols, have led to botched executions, such as the sedative midazolam in Oklahoma and Ohio. That's not the case with pentobarbital, though that's not to say there haven't been problems.
In both Georgia and Texas, placing IVs in the arms of inmates who had been heavy drug users caused some difficulty. Atlanta Journal-Constitution reporter Rhonda Cook said in the case of one execution, the team "couldn't get a vein, and what they had to do is what they call a 'cut down' where they inserted the IV at the base of his neck."
And in 2015, Georgia had to cancel a scheduled execution because the pentobarbital was stored at too cold of a temperature.
"And what happened was the solids that are combined with the liquid to create pentobarbital separated. So there were clumps in the containers that had the pentobarbital," Cook said.
Missouri's protocol calls for inmates to be injected with 5 grams of pentobarbital. That makes for a quick, lethal dose. Witnesses say it looks like little more than someone falling asleep.
"There is seldom anything for us to really talk about except to say the person was executed, might have gasped a couple of times and then became silent and was pronounced dead a few minutes later. ... There's nothing especially dramatic about it. It's very clinical," according to Bob Priddy, the former news director of the statewide radio network Missourinet.
He's witnessed 22 executions in Missouri, including 2 pentobarbital-only ones, and said, "I've never seen any discomfort. In fact ... the media witnesses get a call from the attorney general's office usually the day or so after the execution asking if we had seen any signs of discomfort or any signs of pain or any struggles or anything like that. And the answer that I've always given is 'No. The person just went to sleep.'"
Missourinet's Bob Priddy describes state's execution chamber, what witnesses can see and the chain of events when an inmate is put to death.
Missouri's protocol calls for the medical personnel on the execution team to check whether a prisoner is dead after "a sufficient amount of time." When asked for an estimate of how long that is, Department of Corrections spokesman David Owen said it's about 5 minutes, which Priddy corroborated.
Cook has seen 26 executions in Georgia, many of them with the pentobarbital protocol. She said that witnesses can see inmates' faces.
"You can watch his breathing. Every once in a while you can hear a sound like they might blow, exhale tremendously," she said. "But mostly you can't hear what's going on in the execution chamber."
She continued to describe what happens as the execution begins: "What I've seen on occasion is the inmate will look at one of the arms, like he felt the drugs moving through. ... You can tell it's happening because they will struggle to keep their eyes open. The last one that I saw, he insisted on smiling as much as he could. He would smile and then the smile would drift away and he would, like, shake himself awake and smile again.
"But what happens is you just see them go to sleep. And you can see their chest moving, and then after a while you no longer see their chest moving. ... It's very respectful, as much as it can be. But it's very quiet," she said.
Rhonda Cook, a reporter at the Atlanta Journal-Constitution, talks about Georgia's execution process and what a witness sees during the capital punishment process.
Sourcing pentobarbital
There's a lot at stake with a pentobarbital-only protocol, according to Megan McCracken, an attorney with the Death Penalty Clinic at the University of California-Berkeley law school. She's worked on capital punishment cases since 2003.
One factor, she said, is whether the execution will be free of cruel and unusual punishment as the U.S. Constitution requires. She argued that the public needs to know because it's a "simple question of good government and whether or not the state is disclosing relevant information about its executions or concealing that information."
Pentobarbital is made by 1 of 2 sources: A compounding pharmacy or an FDA-approved manufacturer.
Akorn is the only manufactured-pentobarbital supplier in the U.S. and has said it will not sell to states that use the drug in their executions, and it has asked 3rd-party suppliers to follow suit. A Buzzfeed report in January by former St. Louis Public Radio reporter Chris McDaniel showed that, at some point, Missouri purchased manufactured pentobarbital, but the timing and the amount weren't clear in the now-sealed court documents.
Compounding pharmacies, according to Dunham with the Death Penalty Information Center, are "state regulated and their quality - while they serve an important purpose - their quality varies greatly."
Georgia and Texas are both transparent about obtaining their pentobarbital from compounding pharmacies, although the names of those pharmacies are state secrets. Dunham said that's because the pharmacies don't want people to know they make the drugs so they don't lose business.
The pentobarbital made at compounding pharmacies is "typically produced in anticipation of a pending execution," because it's shelf life is "weeks or months. You're not talking years," Dunham said.
On the other hand, manufactured pentobarbital, known generically as nembutal, is a different story, McCracken said.
"... (W)hat we know is that back when nembutal was available to departments of correction, the expiration date was generally in the range of 2 to 2 1/2 years from the time of purchase," she said.
It's unclear whether Missouri's 34 vials of pentobarbital are manufactured or compounded. The Missouri Department of Corrections did not provide, as asked for in the public records request, expiration dates for the vials, saying the records are closed under state statutes.
Source: KBIA News, August 18, 2017
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